Low Testosterone Low T: Causes, Symptoms & Treatment

Male hypogonadism Symptoms & causes

LOH and low testosterone are more common in men who have Type 2 diabetes, overweight and/or obesity. Symptoms of low testosterone can vary considerably, particularly by age. Make a gift to our 2025 Drive to Cure Cancer and transform the way cancer is treated and defeated.

If you’re experiencing symptoms of low testosterone, such as a decrease in sex drive and hot flashes, talk to a healthcare provider. Conditions that affect how your hypothalamus and/or pituitary gland cause secondary hypogonadism. This is known as hypogonadotropic hypogonadism because there are low levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Those low levels cause decreased testosterone and sperm production. Having male hypogonadism can affect your self-image and, possibly, your relationships. Talk with your health care provider about how you can reduce the anxiety and stress that often accompany these conditions.

Testosterone taken by mouth, also called oral, isn’t often used for treatment of hypogonadism. Your hypothalamus and pituitary gland normally control the amount of testosterone your testicles produce and release. Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition. If a pituitary problem is the cause, pituitary hormones can marijuana lower testosterone be given to help the body make more sperm and restore fertility.

Finding the cause of hypogonadism is an important first step to getting appropriate treatment. Low testosterone (male hypogonadism) is a condition in which your testicles don’t produce enough testosterone (the male sex hormone). More specifically, the Leydig cells in your testicles make testosterone. You can be born with male hypogonadism, or it can develop later in life, often from injury or infection. The effects — and what you can do about them — depend on the cause and at what point in your life male hypogonadism occurs. Some types of male hypogonadism can be treated with testosterone replacement therapy. For congenital hypogonadism, testosterone replacement therapy often helps prevent problems related to delayed puberty.

Any issue with your testicles, hypothalamus or pituitary gland can cause low testosterone (male hypogonadism). Treatment of delayed puberty in boys depends on the cause. Three to six months of testosterone shots can help start puberty. The testosterone can help increase muscle mass, beard and pubic hair growth, and growth of the penis. This treatment is given only if the bones have matured enough. The U.S. Food and Drug Administration has approved one oral testosterone replacement, testosterone undecanoate (Jatenzo, Tlando, Kyzatrex). The lymph system absorbs it, so it might not cause the liver problems seen with other oral forms of testosterone.

Primary hypogonadism happens when something is wrong with your testicles that doesn’t allow them to make normal levels of testosterone. Male hypogonadism is a medical condition that can affect people with testicles at any age from birth through adulthood. Your body usually tightly controls the levels of testosterone in your blood. Levels are typically highest in the morning and decline through the day. Either type of hypogonadism can be caused by an inherited (congenital) trait or something that happens later in life (acquired), such as an injury or an infection. At times, primary and secondary hypogonadism occur together.

In one study, 30% of men who were overweight had low testosterone, compared to only 6% of those with weight in the normal range. In another study, 25% of men with Type 2 diabetes had low testosterone, compared to 13% of those without diabetes. Data suggest that about 2% of men may have low testosterone.

A pituitary tumor may need treatment with surgery, medicine, radiation or replacement of other hormones. Early detection in boys can help prevent problems from delayed puberty. Early diagnosis and treatment in men offer better protection against osteoporosis and other related conditions. Cleveland Clinic’s experts can help balance your hormones.